In residential applications, occupant comfort is affected by temperature, humidity, air motion, clothing, the temperature of the interior surfaces of the room, and the quality of the indoor air. 

The purpose of the HVAC system is to bring these factors in balance with the metabolic activity and the respiratory requirements of the occupants. 

This free download (PDF) provides guidance on minimum/maximum values that contribute to occupant comfort and safety for residential single-zone and multi-zone systems.  Fuller information can be found in ACCA's Manual RS - Comfort, Air Quality, and Efficiency By Design. Order this manual here.

Manual RS provides information about the parameters that define comfort, the factors that affect indoor air quality, zoning issues, the performance of the thermal envelope, systems and system performance characteristics, equipment performance characteristics, equipment selection procedures, and equipment sizing procedures.  

Manual RS guidance is complimented by other ACCA manuals that pertain to specific design procedures -- Manual J (load calculations), Manual S (equipment selection), Manual D (duct system design), Manual T (air distribution devices), and Manual H (heat pumps). 

Taken together, all comprise the recommended ACCA System Design Process.